Max Jan

January 7th, 2021 

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

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Host: Mikolaj Slabicki

Max Jan, MD, PhD, is a pathologist at Massachusetts General Hospital and a postdoctoral fellow co-mentored by Dr. Ben Ebert and Dr. Marcela Maus. Max will present work from the two labs at the interface of protein degradation, synthetic biology, and cellular immunotherapy.

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Link to the recorded seminar: 

Brenda A. Schulman

Max Planck Institute of Biochemistry

January 21st, 2021 

How cullin-RING ligases ubiquitylate structurally diverse substrates

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Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

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Host: Alyssa Verano

Brenda Schulman is a Director at the Max Planck Institute of Biochemistry.  She is broadly interested in how ubiquitin and ubiquitin-like proteins are matched with specific substrates, and how they alter the functions of their targets to regulate the cell cycle, autophagy, metabolic signaling, differentiation and other biological processes.  Her lab structurally visualizes transient ubiquitylation complexes trapped as if in action, biochemically reconstitutes signaling pathways, develops chemical tools to probe ubiquitin signaling, and employs cell biology to investigate how ubiquitylation mediates regulation.  Schulman is an elected member of American Academy of Arts and Sciences, the National Academy of Sciences, EMBO, and the German National Academy Leopoldina, and has been recognized by awards including most recently the Gottfried Wilhelm Leibniz Prize and Ernst Jung Prize for Medicine.