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Previous Speakers (2023 part 2)

Some seminars were recorded and accessible for a limited time on our youtube channel.

Hybrid Meeting: In-Person and over Zoom

September 14th, 2023

12.00-12.30 pm        Arrival and Registration

12:30 -12:35 pm       Welcome Remarks - Dana-Farber Targeted Protein Degradation Organizing Committee

12:35 -1:30 pm         Bill SellersBroad Institute

“Towards a more systematic understanding ubiquitin ligases and their therapeutic utility”

1:30 - 2:00 pm          Fleur M. Ferguson, UCSD

“Interrogating the Druggable Proteome with Proximity Pharmacology”

2:00 - 2:30 pm          Jonathan Tsai, DFCI

“A Common Pathway of Hormone Receptor Degradation: UBR5”

2:30 - 3:30 pm          Light Snack / Coffee Break

3:30 - 4:15 pm          Flash Talks

Katherine Donovan, DFCI, “Chemoproteomic profiling surveys the degradable proteome”

Kevin Dong, HMS, “Reinventing covalent drug discovery for the UPS via multiplexed targeted proteomics”

Ditsa Sarkar, MGH, “Developing a cell therapy suicide switch using  targeted protein degradation.”

Nikki Kong, Center for Protein Degradation, DFCI, "Employing phenotypic assays to dissect on-target mechanisms of molecular glue degraders."

4:15 - 5:00 pm          Panel Discussion: Danette Daniels, Lyn Jones, Sara Buhrlage

5:00 – 5:30 pm         Stephen Elledge, HMS

“Finding Ubiquitin-Dependent and Independent Degrons.”

5:30 – 8:00 pm         Reception (Appetizers and Open Bar)

Event Location:  Linda K. Paresky Conference Center, Simmons College 300 Fenway Boston, MA 02115

The entire event will also be streamed via our standard Zoom link. Please, register only if are able to attend the seminar in person:

Registration Form


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William R. Sellers

Broad Institute

Towards a more systematic understanding ubiquitin ligases and their therapeutic utility

Dr. Sellers is a Core Institute Member and Director of the Cancer Program at the Broad Institute and a Professor of Medicine at the Dana-Farber Cancer Institute and Harvard Medical School. At the Broad Institute he directs a research group focused on translating genomic discoveries into new therapeutics. His lab is focused on both functional genomic approaches to understanding routes for therapeutic development including digenic paralog CRISPR screens, and systematic gain-of-function lethality screens, and on creating new routes for developing therapeutics and understanding therapeutic action. Previously, Dr. Sellers directed cancer drug discovery and early cancer clinical development at the Novartis Institutes for Biomedical Research overseeing all cancer research and clinical sites from 2005-2016. During this time > 30 small molecule, biologic and cell-based cancer therapeutics entered first-in-man trials. Ten therapeutics have reached market approval including encorafinib, alpelisib, ribociclib, asciminib and tisagenlecleucel. During this tenure, he conceptualized and directed the development of Cancer Cell Line Encyclopedia, the Novartis Primary Derived Xenograft Encyclopedia and of large-scale efforts to functionally characterize the cancer genome (Project DRIVE). He previously was an Associate Professor of Medicine at the Dana-Farber Cancer Institute and Harvard Medical School and an Associate Member of the Broad Institute. Together with Matthew Meyerson, he initiated and developed large-scale efforts to resequence genes in diverse cancer types. In addition they pioneered the use of high-density SNP arrays for defining LOH and copy number alterations across cancer including the development of the widely used GISTIC algorithm. These projects led to discovery of EGFR mutations in lung adenocarcinoma and the discovery of the oncogenic role of the MITF gene in melanoma. In addition, his work advanced the understanding of the molecular mechanisms of growth regulation of the PTEN tumor suppressor gene. Dr. Sellers was a member of the National Cancer Advisory Board.  Dr. Sellers received his B.S. from Georgetown University in 1982 and M.D. from the University of Massachusetts Medical School in 1986. He completed residency training in Internal Medicine at the University of California San Francisco in 1989 and trained in Medical Oncology at the Dana-Farber Cancer Institute.


Fleur Ferguson

University of California, San Diego

Interrogating the Druggable Proteome with Proximity Pharmacology

Fleur Ferguson received her M.Sc degree in chemistry from Imperial College London, where she received the Department of Chemistry prize for overall excellence. Dr. Ferguson received her Ph.D in Chemistry from the University of Cambridge funded by a BBSRC studentship, advised by Prof. Chris Abell and Prof. Alessio Ciulli. She then joined DFCI, where she performed her postdoctoral research in the laboratory of Prof. Nathanael Gray. Here, her research focused on modulating kinases with reversible inhibitors, covalent inhibitors, and targeted protein degradation, as well as applying TPD to undruggable targets in neurodegeneration. Dr. Ferguson is currently an Assistant Professor in the Department of Chemistry and Biochemistry, and the Skaggs School of Pharmacy and Pharmaceutical Sciences, at the University of California, San Diego. Her research group focuses on the development and application of proximity-pharmacology technologies to disease areas where traditional targeted therapies have failed, such as neuro-oncology and neurodegeneration. Research in the Ferguson lab has been recognized by numerous prestigious awards including the NIH Directors’ New Innovator Award, the Keck Foundation Research Award, and new investigator awards from the Alzheimer’s Association and the Hilblom Foundation.


Jonathan Tsai

Dana-Farber Cancer Institute/Brigham and Women's Hospital

A Common Pathway of Hormone Receptor Degradation: UBR5.

Jonathan is an Instructor in Pathology at the Brigham and Women's Hospital and postdoctoral scholar in the laboratory of Benjamin Ebert in the Dana-Farber Cancer Institute. He received his MD and PhD from Stanford University. He is broadly interested in protein degradation and its effects on transcriptional regulation and has focused on nuclear hormone receptors as a model for ligand dependent degradation. His long-term goal is to understand and modulate the interaction between the proteasome machinery and hormone receptors with applications towards development, immunology, and cancer biology.


Katherine Donovan

Dana-Farber Cancer Institute/Harvard Medical School

Chemoproteomic profiling surveys the degradable proteome.

Katherine Donovan is a Lead Scientist in the Fischer Lab at Dana-Farber Cancer Institute/Harvard Medical School where she works on the development of molecular-glues and PROTAC molecules for targeted protein degradation. She completed her PhD training in protein biochemistry and structural biology in the lab of Prof Renwick Dobson at the University of Canterbury, New Zealand. After joining the Fischer Lab as a Postdoc she developed an interest in proteomics as a specialized technology for quantifying protein-level expression changes in response to various perturbations. Katherine set up and led proteomics teams focused on degrader screening and target identification in the Fischer Lab as well as in the Center for Protein Degradation. She has used proteomics technology to identify the degradation targets of many molecules including the identification of SALL4 as the protein likely underlying the teratogenicity of thalidomide. Katherine led a large effort to map the degradable kinome and now to aid her quest to map the degradable proteome she has recently started a public degradation proteomics initiative which provides free target mapping of degraders. In recognition of her efforts in the TPD field, Katherine was awarded the Arvinas TPD Early Researcher Award in 2022. Katherine continues to manage and work on several projects related to ligase biology and protein degradation and oversees the TPD proteomics operation in the Fischer Lab and Center for Protein Degradation


Kevin Dong

Harvard Medical School

Reinventing covalent drug discovery for the UPS via multiplexed targeted proteomics.

Kevin Dong is a graduate student in the Biological and Biomedical Sciences PhD program at Harvard Medical School. In the Gygi lab, he develops chemoproteomic platforms that systematically reveal the cellular degradome and rapidly discover chemical probes that target proteins within the ubiquitin-proteasome system (UPS). Powered by an alarming amount of Starbucks coffee, TMT reagents, and a vision for a healthier future, Kevin strives to develop the next-generation of UPS-centric precision medicines.


Ditsa Sarkar

Massachusetts General Hospital

Developing a cell therapy suicide switch using targeted protein degradation.

Ditsa joined Jan lab at MGH in 2022 as a Postdoctoral fellow with a focus on refining cell therapies by harnessing elegant protein degradation machinery. Prior to this, she completed her doctoral training in Biochemistry and Biophysics at National Institute of Immunology, India. Outside work, Ditsa enjoys hiking, EDM & painting.


Nikki Kong

Center for Protein Degradation, Dana-Farber Cancer Institute

Employing phenotypic assays to dissect on-target mechanisms of molecular glue degraders.

Nikki Kong received my PhD in molecular and cell biology from UC Berkeley in the Tjian lab, where as an NSF Graduate Research Fellow, she studied transcriptional regulation of lymphoid-specific hematopoietic differentiation. Nikki Kong then received an NIH T32 fellowship to further her training in Chai and Tenen labs at Brigham and Women’s Hospital/Harvard Medical School. During her postdoctoral training, she determined the DNA binding domain of the transcription factor SALL4, as well as how it interacts with co-factors to regulate transcription in hepatocellular carcinoma cells. Currently, Nikki Kong is the Biology Group Leader at the Center for Protein Degradation at Dana-Farber Cancer Institute. Her group performs phenotypic screens and target validation experiments in order to discover novel molecular glue degraders. 

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Stephen J. Elledge

Harvard Medical School/Brigham and Women’s Hospital

Finding Ubiquitin-Dependent and Independent Degrons.

Stephen J. Elledge is the Gregor Mendel Professor of Genetics and Medicine at Harvard Medical School and the Brigham and Women’s Hospital Division of Genetics, and is a Howard Hughes Medical Institute Investigator. He received his B.S. in chemistry from the University of Illinois and his Ph.D. in biology from the Massachusetts Institute of Technology. He began his laboratory at the Baylor College of Medicine in Houston and moved in 2003 to the Brigham and Women’s Hospital and Harvard Medical School Department of Genetics. He is an elected member member of the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences. His many awards include the Dickson Prize (2010), Lewis S. Rosenstiel Award for Distinguished Work in the Basic Medical Sciences (2013), Gairdner Foundation International Award (2013), Albert Lasker Basic Medical Research Award (2015), Breakthrough Prize in Life Sciences (2017) and the Gruber Prize in Genetics (2017).


Dr. Elledge’s research interests center on genetic approaches to biological problems including the study of proteins that sense and respond to DNA damage, and regulate the cell division cycle and cancer. Through this work he uncovered a protein kinase cascade that is now known as the DNA Damage Response. He discovered F-box proteins and Skp1 and along with Dr. Wade Harper, uncovered the two largest families of E3 ubiquitin ligases: the cullin-RING ligases (CRL), starting with the Skp1-Cul1-F-box sub-family, and the RING domain ligases.  He has also worked in unraveling the role of cancer drivers in the evolution of cancer through aneuploidy and how tumor suppressors allow cancers to evade the immune system. More recently Dr. Elledge has developed a suite of immunological methods, such as T-Scan, VirScan and EpiScan, that allows the genome-wide identification of epitopes recognized by B and T cells. He has used these tools to investigate the role of viruses in human disease such as Measles, MS and COVID-19.



Danette Daniels

Foghorn Therapeutics 

Danette L. Daniels, Ph.D. is a Vice President of the Protein Degrader Platform at Foghorn Therapeutics developing therapeutic degraders in the areas of chromatin biology and oncology. She was an early leader in the field of targeted protein degradation, pioneering approaches to monitor cellular kinetics of degradation, understand mechanism of action, and most recently, co-developing a new PROTAC modality.  She received her PhD in Biophysics at Yale University and was a postdoctoral fellow at Stanford School of Medicine studying the Wnt signaling pathway.


Sara Buhrlage

Dana-Farber Cancer Institute

Sara Buhrlage, PhD is an Associate Professor holding joint appointments in the Dana-Farber Cancer Institute department of Cancer Biology and the Harvard Medical School department of Biological Chemistry and Molecular Pharmacology. Dr. Buhrlage’s research is focused on development of new chemical probes and therapeutic strategies for deubiquitinases (DUBs). Her research has provided new insights into the chemical tractability of DUBs, approaches for illuminating DUB function and therapeutic potential and roles of DUBs in cancer. Dr. Buhrlage earned a Doctor of Philosophy in organic chemistry from the University of Michigan and completed a post-doctoral fellowship at the Broad Institute.


Lyn Jones

Center for Protein Degradation at the Dana-Farber Cancer Institute

Lyn Jones completed PhD studies in synthetic organic chemistry at the University of Nottingham, before starting his postdoctoral research at The Scripps Research Institute, California in chemical biology. He joined Pfizer (Sandwich, UK) as a medicinal chemistry team leader, eventually becoming Director of Chemical Biology and Lead Discovery Technologies. He transferred to Pfizer Cambridge, MA to become Head of Rare Disease Chemistry and Head of Chemical Biology. He then joined Jnana Therapeutics as Vice President of Chemistry and Chemical Biology, before moving to his current role as Director of the Center for Protein Degradation at the Dana-Farber Cancer Institute in Boston. His research interests include the creation and application of chemistry-based technologies that advance therapeutic target identification and accelerate drug discovery. He is an elected Fellow of the American Association for the Advancement of Science, the Royal Society of Chemistry, the Royal Society of Biology, the Royal Society for Public Health, and the Linnean Society, and serves on the editorial board of the journal RSC Medicinal Chemistry and the board of the Medicinal and Bioorganic Chemistry Foundation.

Event sponsors:


September 21st, 2023

Host: Mikolaj Slabicki


William J. Gibson

Dana Farber Cancer Institute

Time Change:

11 am EDT/EST

8 am PT/PST

4 pm BST/BDT


Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation

William J. Gibson MD,PhD is a medical oncology fellow at the Dana Farber Cancer Institute, where he is a Lubin Scholar. His research focuses on novel applications for chemical induced proximity and strategies to drug some of cancers most intractable targets. He is co-mentored by Stuart Schreiber and Matthew Meyerson.

He previously earned degrees in Biological Engineering and Philosophy at the Massachusetts Institute of Technology. He then joined the Harvard-MIT MD/PhD program, where he worked with Rameen Beroukhim on understanding cancer evolution and the therapeutic vulnerabilities of somatic copy number alterations. Gibson completed his residency in internal medicine at Brigham and Women's Hospital.

Link to the recorded seminar:


Yevgeniy Serebrenik

University of Pennsylvania and Children’s Hospital of Philadelphia

Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics

Yevgeniy Serebrenik is a postdoctoral fellow in the lab of Dr. Ophir Shalem at the University of Pennsylvania and Children’s Hospital of Philadelphia, where he developed a high-throughput approach for direct manipulation and visualization of endogenous proteins called Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites (SPOTLITES). Yevgeniy used SPOTLITES to study endogenous proteins capable of degrading various targets upon induced proximity, as well as different protein quality control responses to spatially restricted protein misfolding enabled by combining optical sequencing with pooled hydrophobic targeting. This work was supported by F32 and K99 awards. Prior to his postdoc, he earned his B.S. from Tufts University in 2011 and completed his Ph.D. at Yale University in 2017. At Yale, Yevgeniy worked in the lab of Dr. Craig Crews using small molecule strategies to study protein quality control mechanisms in the Golgi apparatus.

Link to the recorded seminar:


October 5th 2023

Host: Katherine Donovan / Hojong Yoon


Kheewoong Baek

Max Planck Institute of Biochemistry

Assembly and disassembly of cullin-RING ligases

Kheewoong Baek is a postdoctoral fellow in the Fischer lab at the Dana Farber Cancer Institute. Prior to joining the Fischer lab, Khee was at the Max Planck Institute of Biochemistry in the lab of Brenda Schulman for his doctoral studies. His research involved structural and biochemical characterization of neddylated cullin-RING ligases (CRLs) in action during ubiquitylation and CRLs undergoing substrate receptor exchange. Currently, he is trying to find avenues to utilize E3 ligases with chemical tools to modulate them as a therapeutic modality.


Lukas Henneberg

Max Planck Institute of Biochemistry

Activity-based profiling of cullin–RING E3 networks by conformation-specific probes

Lukas Henneberg is a PhD student in the labs of Brenda Schulman and Matthias Mann at the Max Planck Institute of Biochemistry. His work focuses on combining probes specifically targeting active ubiquitin E3 ligases with mass spectrometry-based proteomics to uncover the regulatory mechanisms controlling E3 ligase networks. Before starting his PhD, he obtained a master’s degree from the Freie Universität Berlin, during which conducted research in the lab of Christopher Garcia at Stanford University.

Link to the recorded seminar:

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October 19th 2023

Host: Mikolaj Slabicki / Hojong Yoon

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Jonathan Tsai

Dana-Farber Cancer Institute

Jonathan is an Instructor in Pathology at the Brigham and Women's Hospital and postdoctoral scholar in the laboratory of Benjamin Ebert in the Dana-Farber Cancer Institute. He received his MD and PhD from Stanford University. He is broadly interested in protein degradation and its effects on transcriptional regulation and has focused on nuclear hormone receptors as a model for ligand dependent degradation. His long-term goal is to understand and modulate the interaction between the proteasome machinery and hormone receptors with applications towards development, immunology, and cancer biology. 

Jacob Aguirre

Friedrich Miescher Institute

Jacob Aguirre is a postdoctoral fellow at the Friedrich Miescher Institute in Basel, Switzerland. There, he studies molecular mechanisms of protein degradation in the lab of Nico Thomä. He is particularly interested in how ubiquitin ligase recruitment can be tuned by small molecules and uses a variety of biophysical techniques, including cryo-EM, to study these processes at the atomic level. 

Kevin Mark.tiff

Orphan quality control shapes network dynamics and gene expression

Kevin Mark

University of California, Berkeley

Kevin received his Ph.D. from the University of California, San Francisco while studying with David Toczyski and continued his work as a postdoctoral fellow in the laboratory of Michael Rapé at the University of California, Berkeley. His scientific career has focused on determining the role of protein ubiquitylation in different eukaryotic systems using a wide range of biochemical approaches. His long-term goal is to understand how ubiquitin-mediated protein quality control regulates gene expression during development, and to modulate these processes using small molecules for the treatment of diseases, such as cancer and neurodegeneration.


Durga Kolla

University of California, Berkeley

Durga Kolla is a Ph.D. candidate at the University of California, Berkeley in the laboratory of Michael Rapé. She is interested in investigating the molecular mechanisms underlying protein degradation pathways in development and disease. Her dissertation work focuses on quality control of protein complex composition in transcription. She would like to further her career by  exploring the development of ubiquitin ligase targeted therapeutics and drug discovery. 

Link to the recorded seminar:


November 2nd 2023

Host: Katherine Donovan


Luca Naef


Current and future approaches of accelerating induced proximity through AI

Luca Naef is Co-Founder & CTO of VantAI, a Biotech focused on an AI-first approach at unlocking the potential of induced proximity. VantAI is a trusted partner to and has achieved multiple pre-clinical milestones with several major pharmaceutical & biotechs in the protein degradation field, successfully applying AI across a range of novel effectors and difficult to drug targets.

Luca received his BSc and MSc and signficant research experience across ETH Zurich, Standford and other global institutions, and has worked extensively in the AI field both as a researcher, software engineer and devising and implementing the AI strategy of global pharmaceutical companies as part of McKinsey & Company's QuantumBlack unit.

Link to the recorded seminar:

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Andrew Potterton


Using technology to drive structure-based design of proximity-inducing compounds

Andrew Potterton is the Head of Platform at CelerisTx where he is responsible for all technology efforts within the company. Prior to joining CelerisTx, Andrew spent 3 years at BenevolentAI leading a squad that developed internal tools for both TargetID and Chemistry. He completed his PhD at the Institute of Structural and Molecular Biology, University College London and Evotec in computational chemistry and machine learning focussed around GPCR drug discovery. Also at University College London, Andrew obtained a BSc in Biochemistry.

Link to the recorded seminar:


November 16th 2023

Host: Hojong Yoon / Breanna Zerfas


Basel Karim & Roman Sarott

Stanford University, Stanford Cancer Institute

Borrowing Transcriptional Kinases Using Chemically Induced Proximity


Basel is a graduate student in the Department of Chemistry at Stanford University. He graduated from Pennsylvania State University, receiving his B.S. in Biochemistry/Molecular Biology and Chemistry. During his undergraduate studies, he worked with Dr. Xin Zhang on developing fluorescent probes to monitor protein aggregation processes. In his graduate studies with Dr. Nathanael Gray, Basel is focused on developing chemical-induced proximity strategies to study and rewire cellular signaling programs in dysregulated diseases.


Roman did his PhD at ETH Zürich under the supervision of Erick M. Carreira, where he worked on optochemical probes for the study of cannabinoid receptors. As an SNSF Postdoctoral Fellow in the group of Nathanael Gray at the Stanford Cancer Institute, his research focuses on leveraging chemical inducers of proximity to activate silenced cellular signaling, in particular on context-specific modulation of transcription. 

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Shuang Liu

Broad Institute and Harvard University

Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations

Shuang Liu is a senior scientist at the Institute of Molecular and Cell Biology, A*STAR, Singapore. She pursued her undergraduate studies in Chemistry with Medicinal Chemistry at Imperial College London with full funding from A*STAR’s National Science Scholarship (BS). She then spent a year at A*STAR's Experimental Therapeutics Centre in Singapore and identified several exploratory and lead stage therapeutic compounds using fragment-based screening. She obtained her DPhil in Chemical Biology at the University of Oxford under the guidance of Prof. Christopher Schofield, funded by the National Science Scholarship (PhD), focusing on mechanistic and inhibition studies on oncogenic variants of Isocitrate Dehydrogenase 1. Subsequently, Shuang moved from the UK to the US for her postdoctoral training in the laboratory of Prof. Stuart Schreiber at the Broad Institute of MIT and Harvard/Harvard University, where she harnessed the power of DNA-encoded library screening to discover binders and molecular glues for oncogenic targets.


November 30th 2023

Host: Zuzanna Kozicka


Xin Zhou

Dana-Farber Cancer Institute

Transferrin Receptor Targeting Chimera (TransTAC) for Membrane Protein Degradation 

Xin Zhou is an Assistant Professor in the Cancer Biology Department at the Dana-Farber Cancer Institute and the Biological Chemistry & Molecular Pharmacology Department at Harvard Medical School. She completed her Ph.D. in Bioengineering at Stanford University with Dr. Michael Lin and trained as a Damon Runyon Postdoctoral Fellow at the University of California, San Francisco, with Dr. James Wells. Working at the interface of biomolecular engineering and disease biology, the Zhou Lab is developing innovative biotechnologies and biomedicines for complex diseases that have traditionally been challenging to address. Our research projects encompass the development of protein-based PROTACs or antibody-drug conjugates to target challenging human diseases such as non-small cell lung cancer, designing allosteric protein switches to modulate immune responses, and biosensing of disease environments to inform the pro-drug designs. Xin is a recipient of the K99/R00 Pathway to Independence Award, the Damon Runyon Dale F. Frey Award for Breakthrough Scientist, and the DP2 NIH Director's New Innovator Award.


December 14th, 2023

Host: Mikolaj Slabicki / Katherine Donovan

Radosław Nowak

University of Bonn

Structure based design of covalent cereblon binders, glues and PROTACs

Radosław Nowak is a Professor of Immune Engineering and Drug Discovery at the University of Bonn and a Steering Committee Member of the ImmunoSensation2 Cluster of Excellence in Bonn. Prior to joining University of Bonn Dr. Nowak completed a postdoctoral fellowship and became a senior scientist at the laboratory of Prof. Eric S. Fischer and a group leader and a member of the leadership team at the Center for Protein Degradation at the Dana-Farber Cancer Institute in Boston. Dr. Nowak’s research focuses on development of degrader molecules and characterization of novel mechanisms of degradation. In his work, Dr. Nowak uncovered mechanistic principles that govern selectivity of targeted protein degraders including determination of first structures of cereblon with PROTAC molecules as well as developed molecular glue degraders of novel transcription factors. Dr. Nowak received a master’s degree in engineering science at the University of Oxford, and a DPhil in Systems Approaches in Biomedical Science IDC at the University of Oxford working with Prof. Udo Oppermann to study and identify small molecule inhibitors of histone lysine demthylases and ribosomal hydroxylases.


Christian Steinebach

University of Bonn

Targeting the Ubiquitin-Proteasome-System with PROTACs

Christian Steinebach is a Postdoctoral Researcher at the University of Bonn's Pharmaceutical Institute, where he focused on the synthesis of PROTAC molecules. He successfully finished his PhD viva in Pharmaceutical Chemistry at the University of Bonn in 2020 and has since aspired for an independent academic career with a focus on induced-proximity modalities. Alongside with internationally renowned scientists, he was able to identify selective PROTAC degraders of the E3 ligases CRBN and IAPs. In addition to homo- and heterobifunctional ubiquitin ligase degraders, his team developed PROTACs that target pharmaceutically-relevant kinases, epigenetic reader proteins, and deubiquitinases. Furthermore, his Medicinal Chemistry portfolio includes the discovery of optimized E3 ligase ligands as well as the improvement of physicochemical features of PROTACs.

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