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September 12th, 2024

2024 DFCI-TPD In Person Meeting

12.00-12.30 pm Arrival, Registration and Boxed lunch

12:30 -12:40 pm  Welcome Remarks

Dana-Farber Targeted Protein Degradation Organizing Committee Mikołaj Słabicki, Katherine Donovan

12:40 -1:40 pm    Keynote: Eric Fischer, DFCI, host: Katherine Donovan

Molecular Mechanisms of Ubiquitin Ligases. From Structure to Therapies

1:40 - 2:10 pm     Mikołaj Słabicki, MGH/DFCI/Broad Institute, host: Hojong Yoon

Expanding the human zinc finger degrome targeted by glutarimide analogs through CRBN

2:10 - 2:40 pm     Samantha Bevill, DFCI, host: Breanna Zerfas

Tumor-specific PROTACs that exploit amplification of the MDM2 E3 ubiquitin ligase

2:40 – 3:15 pm    Light snack / Coffee break

 

3:15 – 3:45 pm    Pamela Ting, Novartis, host: Zuzanna Kozicka

A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction

3:45 – 4:15 pm    Liron Bar-Peled, MGH, host: Samuel Ojeda

An Omics Approach to Drug Discovery

 

4:15 – 5:30 pm    Panel Discussion, Moderator: Breanna Zerfas
Samantha Nelson, Scientific Editor, Cell Chemical Biology
Sheryl Gough, Associate Director of Oncology Discovery, Arvinas
Chris Bahl, President/CSO/Co-founder, AI Proteins

 

5:30 – 8:00 pm    Reception (Appetizers and Open Bar)

 

Event Location:  Linda K. Paresky Conference Center, Simmons University 300 Fenway Boston, MA 02115.

There is a limited number of registration slots available and is based on the seminar room capacity. Registration will work on a first come first served basis. Registration is free of charge, but please cancel your registration (drop line to DFCI.TPD@gmail.com) if you cannot join to allow space for others.

Event organized by:

Dana-Farber Targeted Protein Degradation Organizing Committee
Mikolaj Slabicki, Katherine Donovan, Hojong Yoon, Breanna Zerfas, Zuzanna Kozicka, Samuel Ojeda

Sponsored by:

Speakers:

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Eric Fischer

DFCI

Molecular Mechanisms of Ubiquitin Ligases. From Structure to Therapies

Eric Fischer, Ph.D. is the Director of the Chemical Biology Program at Dana-Farber Cancer Institute, Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, Director of the DFCI Center for Protein Degradation, and Co-Director of the Center for Therapeutics Discovery. Dr. Fischer trained in structural biology and biochemistry at the University of Basel and conducted his doctorate studies at the Friedrich Miescher Institute for Biomedical Research. His lab at Dana-Farber focusses on the understanding of fundamental processes in ubiquitin signaling, and the molecular basis of ubiquitin ligase activity, targeting and regulation. His lab seeks to leverage this understanding for the development of novel therapeutic approaches, such as targeted protein degradation. He and his lab have significantly contributed to our understanding of small molecule mediated protein degradation, and its widespread application in academia and industry.

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Mikołaj Słabicki

MGH/DFCI/Broad Institute

Expanding the human zinc finger degrome targeted by glutarimide analogs through CRBN

Mikołaj Słabicki earned his Ph.D. at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Dr. Słabicki then conducted his post-doctoral research as a Marie Skłodowska Curie Scholar in Dr. Benjamin Ebert’s laboratory at the Dana-Farber Cancer Institute and in Stefan Fröhling’s laboratory at the German Cancer Research Center in Heidelberg, Germany. Mikołaj Słabicki later became a Group Leader in the Cancer Program at the Broad Institute, a member of Dr. Benjamin Ebert’s Laboratory, and a Senior Staff Scientist at the Dana-Farber Cancer Institute. In the summer of 2024, Mikołaj began a faculty position at the Massachusetts General Hospital (MGH) Cancer Center. His laboratory aims to expand the druggable proteome by employing functional genomics, high-throughput screening, chemical biology, cell biology, and biochemical techniques to identify and characterize new molecular glue degraders and novel mechanisms of targeted protein degradation.

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Samantha Bevill

DFCI

Tumor-specific PROTACs that exploit amplification of the MDM2 E3 ubiquitin ligase.

Samantha Bevill, PhD is a research fellow in the Bernstein and Qi labs at the Dana-Farber Cancer Institute. Her research interests are rooted in understanding fundamental mechanisms of tumor biology that can be leveraged to design selective cancer therapeutics. She received her B.S. in Biology from Clemson University in 2012 and her Ph.D. in Pharmacology from the University of North Carolina at Chapel Hill in 2018. Her doctoral work in Dr. Gary Johnson’s lab used proteomic techniques to identify compensatory signaling pathways responsible for adaptive resistance to targeted kinase inhibitor therapies in breast cancer. As a post-doctoral fellow in Dr. Bradley Bernstein’s laboratory, she led a large project that sought to define the transcriptional regulatory landscape of liposarcoma. Her work defined a novel P53-independent role for MDM2 occupancy across the genome. This work defines supraphysiologic MDM2 as having a novel role in highly amplified tumors and revealed MDM2 high cells mediate therapeutic resistance. Concurrent to this work, she has collaborated closely with the lab of Jun Qi to establish new therapeutic strategies for selective targeting of highly MDM2-amplified tumor subpopulations using PROTAC degraders.

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Pamela Ting

Novartis

A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.

Pam is an Associate Director at Novartis Biomedical Research where she leads internal and external collaboration teams to develop therapies for classical hematology and hematologic malignancies. Pam has broad expertise in drug development from target discovery to IND and experience across multiple innovative platforms including degraders, cell and gene therapy. She received her B.A. in Molecular & Cellular Biology from University of California, Berkeley, her Ph.D. in Biological Chemistry from University of California, Los Angeles, studying the regulation of BCR-ABL in chronic myelogenous leukemia, and studied allogeneic hematopoietic stem cell transplantation as a postdoctoral fellow at the Genomics Institute of the Novartis Research Foundation.

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Liron Bar-Peled

MGH

An Omics Approach to Drug Discovery

Liron received his Bachelor of Science degree in Biochemistry from the University of Georgia in 2004. Liron received his PhD in Biology from the Massachusetts Institute of Technology, where he used advanced cellular and molecular techniques to uncover how nutrients are sensed by the mTORC1 pathway in the laboratory of David Sabatini. In 2013 as a Damon Runyon Postdoctoral fellow, he joined the laboratory of Ben Cravatt at the Scripps Research Institute to understand how cancer cells respond to oxidative stress. Employing chemical, proteomic and biochemical approaches, Liron revealed new druggable components of the NRF2 antioxidant response pathway uncovering new mechanisms by which NRF2 regulates metabolic pathways. In early 2019, Liron joined the Center for Cancer Research at the Massachusetts General Hospital and the Department of Medicine at Harvard Medical School. He is currently an Associate Professor of Medicine in Biological and Biomedical Sciences.

Panelists:

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Samantha Nelson

Scientific Editor, Cell Chemical Biology

Samantha originates from central Florida, where she grew up and earned her bachelor's and master's degrees. She then relocated to Massachusetts to pursue her PhD in Immunology and Microbiology at UMass Chan Medical School. During her doctoral studies, Samantha delved into metabolism, metal biology, antibiotic development, and genetic engineering techniques in Mycobacterium tuberculosis. After completing her PhD, she joined Cell Chemical Biology as a scientific editor. Although her academic background is rooted in microbiology, Samantha is endlessly curious about all facets of biology and is passionate about facilitating the dissemination of scientific research. In her leisure time, she channels her curiosity into identifying native animal and plant species, exploring historical costuming techniques, and learning to lindy hop.

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Sheryl Gough

Associate Director of Oncology Discovery, Arvinas

Sheryl Gough is currently an Associate Director in the Oncology/Biology team at Arvinas Operations, Inc., New Haven, Connecticut. Sheryl has contributed to multiple PROTAC programs at Arvinas over the past nine years, including leading studies for the preclinical in-vivo pharmacology of Vepdegestrant (ARV-471, an estrogen receptor (ER) degrading PROTAC) for the treatment of ER+ breast cancer, and is the biology lead for ARV-393, a BCL6 PROTAC recently progressed to Phase I trials for non-Hodgkin lymphoma. Prior to Arvinas, Sheryl was a Visiting Post-Doctoral Fellow at the NCI/NIH with Dr Peter Aplan for six years working on murine models of hematological malignancies and NUP98-gene fusions. Sheryl received her PhD in cancer genetics in 2003 from the University of Otago, New Zealand, where her work focused on characterizing chromosome translocations and gene mapping in leukemia patients under the mentorship of Dr Christine Morris at the Christchurch School of Medicine, University of Otago.

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Chris Bahl

President/CSO/Co-founder, AI Proteins

Christopher D. Bahl, MS, PhD is a protein designer, biochemist, structural biologist and entrepreneur. Chris pioneered the ability to computationally design miniproteins de novo as a postdoctoral fellow with David Baker at the Institute for Protein Design in Seattle. In 2017, Chris joined the Institute for Protein Innovation in Boston as one of the founding faculty members, with co-appointments at Boston Children's Hospital and Harvard Medical School. In 2021, Chris and members of his laboratory left academia together to found AI Proteins, Inc., where Chris currently serves as the President and Chief Scientific Officer. AI Proteins is leveraging the power of miniproteins to rapidly create novel therapeutics de novo, a game-changing approach with the potential to transform the pharmaceutical industry.

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September 26th, 2024

Host: Hojong Yoon

Gopal Sapkota

University of Dundee

Targeted dephosphorylation of phospho-proteins through induced-proximity

Gopal is originally from Nepal but obtained a Masters degree in Biochemistry from the University of Bath in 1999. Gopal received his Ph.D. from the University of Dundee in 2003 and then joined Joan Massagué’s laboratory at Memorial Sloan-Kettering Cancer Center in New York, to undertake postdoctoral research to study the TGFβ pathway regulation, for which he received the prestigious Damon Runyon Cancer Research Fellowship. Gopal returned to Dundee in November 2008 to start his group at the MRC PPU, and in 2014 became a tenured Programme Leader.

 

Lab research: https://sites.dundee.ac.uk/sapkota-lab/

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