Alyssa Verano, PhD

Gray Lab

Alyssa Verano is a postdoctoral research fellow in Prof. Nathanael Gray’s lab where she works on the synthesis and development of molecular glues and heterobifunctional molecules for targeted protein degradation. She completed her PhD training in organic chemistry and pharmacology under the supervision of Prof. Derek Tan at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College. Her graduate research centered on the stereoselective synthesis and biological evaluation of spiroketal natural products. Since joining the Gray Lab in 2017, Alyssa has led chemistry efforts to develop monovalent degraders of transcription factors and novel neo-substrates. In addition to molecular glues, she has designed and synthesized novel ligands to target the E3 ligase Cereblon, as well as bispecific degraders to target kinases. Her research has also focused on structure-based drug design and medicinal chemistry optimization of covalent inhibitors of several kinase targets.