The Webinar Series will take place bi-weekly on: Thursdays
12 pm noon (EST)
9 am (PST), 5 pm (GMT), 6 pm (CET)
We will use a single Zoom webinar registration for the upcoming seminars:
https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Some seminars might be recorded and accessible for a limited time.
Upcoming Speakers
Danette Daniels
Promega Corporation
March 4th, 2021
Unlocking the dynamic cellular mechanisms of targeted protein degradation
Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Host: Breanna Zerfas
Danette received her B.A. from Columbia University, a Ph.D. in Biophysics from Yale University, and completed a postdoctoral fellowship at Stanford University School of Medicine studying the Wnt signaling pathway. In 2005 she joined Promega Corporation and is currently a R&D Group Leader of Functional Proteomics. In her time at Promega she has led innovation and applications of HaloTag, chemoproteomics, NanoBRET, and HiBiT luciferase technologies. Danette is known for her extensive research collaborations, both with academic laboratories as well as biotech and pharma companies. These partnerships have resulted in discoveries of several novel epigenetic and transcription complexes, as well as characterization of numerous therapeutic inhibitors. Several years ago she and her team shifted focus to TPD, immediately developing approaches to monitor real-time kinetics of degradation and PROTAC induced interactions. These efforts have advanced understanding of cellular potency, efficacy, and mechanisms of degradation compounds.
David Komander
Walter and Eliza Hall Institute of Medical Research
March 18th, 2021
Deubiquitinases: Opportunities, observations and open questions
Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Host: Katherine Donovan
David Komander studied in Germany and Scotland, working on protein kinase structures during his PhD in Dundee. As a postdoc in London, he initiated work on tumour suppressor deubiquitinases, leading to the first structures on CYLD and A20. Focussing on E3 ligases, ubiquitin binding domains and deubiquitinases, he went on to set up his own highly successful research group at the MRC Laboratory of Molecular Biology in Cambridge, UK. He was recipient for the Lister prize in 2012 and became an EMBO member in 2014.
At the end of 2018 David Komander moved to Australia to become head of the newly founded Ubiquitin Signalling Division at the Water and Eliza Hall Institute in Parkville, Australia.
April 1st, 2021
TBA
Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Host: Breanna Zerfas
Matthew Disney
Scripps Research, Florida
April 15th, 2021
TBA
Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Host: Katherine Donovan
Debbie Chirnomas
Arvinas
April 29th, 2021
TBA
Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Host:
Georg Winter
CeMM Research Center for Molecular Medicine
May 13th, 2021
Identification and characterization of molecular glue degraders
Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ
Host: Mikolaj Slabicki
Georg Winter performed his PhD studies with Giulio Superti-Furga, working on elucidating the mechanism of action of anti-neoplastic drugs. He continued his training in chemical biology, working as a postdoc with James Bradner at the Dana Farber where he developed the first generalizable pharmacologic solution to in vivo target protein degradation via phthalimide-conjugation. He was recruited as a CeMM PI in 2016 where his research is focused on deploying targeted protein degradation to understand and disrupt fundamental principles of gene control in cancer. His interdisciplinary research lab is supported by several national and international grants and fellowships including an ERC Starting Grant. Dr. Winter’s contribution to the field of targeted protein degradation was acknowledged via multiple prices and awards, including the Eppendorf Award 2019 and the Elisabeth Lutz Award of the Austrian Academy of Sciences.
Winter-lab.com