The Webinar Series will take place bi-weekly on: Thursdays

12 pm noon (EST)

9 am (PST), 5 pm (GMT), 6 pm (CET)

We will use a single Zoom webinar registration for the upcoming seminars:

https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

Some seminars might be recorded and accessible for a limited time.

 

Upcoming Speakers

Danette Daniels

Promega Corporation

March 4th, 2021 

Unlocking the dynamic cellular mechanisms of targeted protein degradation

Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

 

Host: Breanna Zerfas

 
 
 
 
 

Danette received her B.A. from Columbia University, a Ph.D. in Biophysics from Yale University, and completed a postdoctoral fellowship at Stanford University School of Medicine studying the Wnt signaling pathway.  In 2005 she joined Promega Corporation and is currently a R&D Group Leader of Functional Proteomics.  In her time at Promega she has led innovation and applications of HaloTag, chemoproteomics, NanoBRET, and HiBiT luciferase technologies.  Danette is known for her extensive research collaborations, both with academic laboratories as well as biotech and pharma companies.  These partnerships have resulted in discoveries of several novel epigenetic and transcription complexes, as well as characterization of numerous therapeutic inhibitors. Several years ago she and her team shifted focus to TPD, immediately developing approaches to monitor real-time kinetics of degradation and PROTAC induced interactions.  These efforts have advanced understanding of cellular potency, efficacy, and mechanisms of degradation compounds.

David Komander

Walter and Eliza Hall Institute of Medical Research

March 18th, 2021 

Deubiquitinases: Opportunities, observations and open questions

Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

 

Host: Katherine Donovan

 

David Komander studied in Germany and Scotland, working on protein kinase structures during his PhD in Dundee. As a postdoc in London, he initiated work on tumour suppressor deubiquitinases, leading to the first structures on CYLD and A20. Focussing on E3 ligases, ubiquitin binding domains and deubiquitinases, he went on to set up his own highly successful research group at the MRC Laboratory of Molecular Biology in Cambridge, UK.  He was recipient for the Lister prize in 2012 and became an EMBO member in 2014.

At the end of 2018 David Komander moved to Australia to become head of the newly founded Ubiquitin Signalling Division at the Water and Eliza Hall Institute in Parkville, Australia.

April 1st, 2021 

TBA

Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

 

Host: Breanna Zerfas

 
 
 
 
 

Matthew Disney

Scripps Research, Florida

April 15th, 2021 

TBA

Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

 

Host: Katherine Donovan

 
 
 
 
 

Debbie Chirnomas

Arvinas

TBA

TBA

 

April 29th, 2021 

TBA​

Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

 

Host: 

 
 

Georg Winter

CeMM Research Center for Molecular Medicine

May 13th, 2021 

Identification and characterization of molecular glue degraders

Webinar registration: https://dfci.zoom.us/webinar/register/WN_m7JJaw52T8yZYt8-ykL6UQ

 

Host: Mikolaj Slabicki

 
 

Georg Winter performed his PhD studies with Giulio Superti-Furga, working on elucidating the mechanism of action of anti-neoplastic drugs. He continued his training in chemical biology, working as a postdoc with James Bradner at the Dana Farber where he developed the first generalizable pharmacologic solution to in vivo target protein degradation via phthalimide-conjugation. He was recruited as a CeMM PI in 2016 where his research is focused on deploying targeted protein degradation to understand and disrupt fundamental principles of gene control in cancer. His interdisciplinary research lab is supported by several national and international grants and fellowships including an ERC Starting Grant. Dr. Winter’s contribution to the field of targeted protein degradation was acknowledged via multiple prices and awards, including the Eppendorf Award 2019 and the Elisabeth Lutz Award of the Austrian Academy of Sciences.

Winter-lab.com