Jianwei (John) Che, Ph.D.

DFCI, Cancer Biology

Jianwei (John) Che, Ph.D., is the Director of the Computational Chemistry Core in the Department of Cancer Biology at the Dana-Farber Cancer Institute. He earned his Ph.D. in Chemistry from the University of California, San Diego, under the mentorship of Prof. Kent R. Wilson, and completed his postdoctoral training in the laboratory of Prof. William A. Goddard III at the California Institute of Technology (Caltech), in the Department of Chemistry and Chemical Engineering. Dr. Che’s research focuses on the development and application of molecular modeling and machine learning approaches to discover and optimize selective small molecules that modulate protein function. His current work centers on covalent small molecule discovery and small molecule-induced protein–protein interactions, such as molecular glues. Before joining Dana-Farber, Dr. Che was a Senior Research Investigator at the Genomics Institute of the Novartis Research Foundation, where he applied computational methods to support small molecule drug discovery projects and biomarker research. Over the years, he has contributed significantly to a few small molecules under the preclinical and clinical development.